Common Methods for Performing Mendelian Randomization
نویسندگان
چکیده
منابع مشابه
5. Mendelian randomization
Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies. Mendelian randomization, the random assortment of genes from parents to offspring that occurs during gamete formation and conception provides one method for assessing the causal nature of so...
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MendelianRandomization is a software package for the R open-source software environment that performs Mendelian randomization analyses using summarized data. The core functionality is to implement the inverse-variance weighted, MR-Egger and weighted median methods for multiple genetic variants. Several options are available to the user, such as the use of robust regression, fixed- or random-eff...
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• betaX and betaXse are both numeric vectors describing the associations of the genetic variants with the exposure. betaX are the beta-coefficients from univariable regression analyses of the exposure on each genetic variant in turn, and betaXse are the standard errors. • betaY and betaYse are both numeric vectors describing the associations of the genetic variants with the outcome. betaY are t...
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Background The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of ge...
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Mendelian randomization studies typically have low power. Where there are several valid candidate genetic instruments, precision can be gained by using all the instruments available. However, sporadically missing genetic data can offset this gain. The authors describe 4 Bayesian methods for imputing the missing data based on a missing-at-random assumption: multiple imputations, single nucleotid...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2018
ISSN: 2297-055X
DOI: 10.3389/fcvm.2018.00051